AN UNBIASED VIEW OF PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved household of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to different stimuli12, triggering the integra